Evaluation of Body Weight, Serum Lipid Profile, Glucose Homeostasis, Oxidative Stress and Hepatic Function in Healthy Mice Fed With Zinc Sulphate Supplementation

The present research study was designed to evaluate the effect of zinc supplementation on body weight, serum triglyceride, cholesterol, glucose homeostasis, oxidative stress, and hepatic function in mice. Mice were treated with sulphate at an equivalent weight 6.5 mg/kg-body elemental for four weeks. Bodyweight, glucose, MDA, nitric oxide, vitamin C, enzymes level determined end period. Data from this showed that mice maintained a balanced blood homeostasis throughout experimental Moreover, treatment significant (p <0.05) decrease triglyceride cholesterol along compared control. Treatment significantly attenuated rate lipid peroxidation whereas increased C NO level. protective liver activity observed. strong negative association total (r= -0.934, p = 0.02), triglycerides -0.709, 0.05), -0.899, 0.01). findings demonstrate can be helpful maintain ameliorate hyperlipidemia, dysfunction. Therefore, suggested alleviate diseases associated metabolic syndrome stress.
 Dhaka Univ. J. Pharm. Sci. 20(1): 59-66, 2021 (June)